A direct transfer would be about 3.5-4h drive and you would arrive around 1pm. In Prague after a quick fresh up, we could take you somewhere to eat where we could go over anything you might want to know or need assistance with. If you want we can discuss any type of touring or just leave you to your own exploring.
However, why just spend the day on a straight transfer when you could also see some other places in the Czech Republic.
If you have time and want to take it easy with a bit of extra sightseeing, then Cesky Krumlov is a great alternative route to Prague. Click on the alternative above the calculator, on the right, to see the cost and what to expect.